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Pathophysiology

• Epstein-Barr virus infection

Contextual Factors

• Kissing
• Crowded situations

Clinical Manifestation

Constitutional

• Fever
• Significant fatigue (lasts several months)
• Atypical lymphocytosis

HEENT

• Tonsillitis/ pharyngitis w/ or w/o exudate
• Posterior/ diffuse cervical lymphadenopathy

GI

• W/ or w/o hepatosplenomegaly
• Transient hepatitis

Skin

• W/ or w/o rash after amoxicillin

Complications

• Acute airway obstruction
• Autoimmune hemolytic anemia
• Thrombocytopenia
• Splenic rupture

Diagnosis

• Positive heterophile antibody (Monospot) test

Treatment

• Supportive care

Acute Airway Obstruction

• Corticosteroids: decreases airway edema